Association of Anti-VEGF Injections with Progression of Geographic Atrophy
نویسندگان
چکیده
Age-related macular degeneration (AMD) is one of the leading causes of blindness in developed countries in people over the age of 60 years. One of the forms of advanced AMD is wet AMD. Wet AMD is a result of leakage and bleeding from abnormal neovascularization. The principal treatment for wet AMD is intravitreal anti-VEGF injections. A second form of advanced AMD is geographic atrophy (GA). GA refers to large areas of retinal pigment epithelium loss. In the literature, there is some concern that anti-VEGF injections administered to treat wet AMD may be associated with progression of GA. This review discusses evidence suggesting the association of anti-VEGF injections with progression of GA.
منابع مشابه
Type 1 neovascularization may confer resistance to geographic atrophy amongst eyes treated for neovascular age-related macular degeneration
BACKGROUND To report a series of age-related macular degeneration (AMD) patients in whom progression to geographic atrophy (GA) in one eye receiving frequent intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) therapy for type 1 neovascularization (NV) was slower than that of the fellow eye with non-neovascular AMD. METHODS Retrospective, observational case series e...
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Submit Manuscript | http://medcraveonline.com anti-vascular endothelial growth factor (VEGF) injections. This therapy has been used to inhibit CNV and protect the retina against leakage. However, the vast majority of AMD patients have the currently untreatable dry or atrophic form of AMD, which is characterized by inflammation-driven degeneration of the retinal pigment epithelium (RPE) [1]. Geo...
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